| Zhang, X.L., Moskal, J.R., and Stanton, P.K. (2008) GLYX-13, a peptide partial agonist at the NMDA receptor glycine site, simultaneously
enhances LTP and depresses LTD at Schaffer collateral-CA1 synapses in hippocampus. Neuropharmacology. 2008 Dec; 55(7):1238-50. |
| (First evidence of GLYX-13 unique mechanism of action: showing ability to increase LTP and decrease LTD) |
| |
| Wood, P.L., Mahmood, S.A., Moskal, J.R. (2008) Antinociceptive action of GLYX-13: an NMDA receptor glycine site partial agonist.
Neuroreport. 2008 Jul 2; 19(10):1059-61. |
| (First publication of GLYX-13 general NMDA properties relative to known other NMDA programs; and in vivo antinociceptive models comparable to
FDA approved neuropathic pain drug, gabapentin) |
| |
| Moskal, J.R, J.R. Kuo, A.G, Weiss, C., Kelso, S., O'Connor Hanson, A., Wood, P.L., and Disterhoft, J.F. (2005) Glyxins:
monoclonal antibody-derived peptides that act as partial agonists at the glycine site of the N-methyl-D-aspartate receptor.
Neuropharmacology 49: 1077-1087. |
(Paper describes the conversion of a monoclonal antibody into a small peptide mimetic with cognitive enhancing properties) |
| |
| Wood PL. (2005) The NMDA receptor complex: a long and winding road to therapeutics. IDrugs. Mar; 8(3):229-35. | >
| (A highly relevant review of the history and development opportunities of NMDA as a therapeutic target in multiple CNS disorders) |
| |
| Moskal, J.R., Yamamoto, H., and Colley, P.A. (2001) The use of antibody engineering to create novel drugs that target
N-methyl-D-aspartate receptors. Current Drug Targets. 2: 331-345. |
| (Review of GLYX-13 & it’s creation from a monoclonal antibody with NMDA receptor, glycine site-specific partial antagonist properties) |
| |
| Thompson, L.T., Moskal, J.R., and Disterhoft, J.F. (1992) Hippocampus-dependent learning facilitated by a monoclonal antibody
or D-cycloserine. Nature 359: 638-641. |
| (First report showing monoclonal antibody enhancement of learning and memory in an animal model) |
| |
| Haring, R., Stanton, P.K., Scheideler, M., and Moskal, J.R. (1991) Glycine-like modulation of NMDA receptors by a monoclonal antibody
that enhances long-term potentiation. J.Neurochem., 57: 323-332. |
| (First report showing a monoclonal antibody enhancing learning and memory formation and its mechanism of action) |
| |
| Stanton, P.K., Sarvey, J.M., and Moskal, J.R. (1987) Inhibition of the production and maintenance of long-term potentiation in rat
hippocampal slices by a monoclonal antibody. Proc. Natl. Acad. Sci. U.S.A. 84: 1684-1688. |
| (First report showing modulation of learning and memory using a monoclonal antibody) |
| |
| Moskal, J.R. and Schaffner, A.E. (1986) Monoclonal antibodies to the dentate gyrus: Immunocytochemical characterization and flow
cytometric analysis of hippocampal neurons bearing unique cell-surface antigen. J. Neurosci., 6(7): 2045-2053. |
| (Seminal publication of original monoclonal antibody work) |
